| Solanum roemerianum Scheele, 1848 |
| Solanum rugosum Dunal, 1852 |
| Solanum salamanii Hawkes, 1944 |
| Solanum salviaefolium Dunal, 1852 |
| Solanum salviifolium Lam., 1793 |
| Solanum sarmentosum Sessé & Moc., 1892 |
| Solanum schiedeanum Schltdl., 1847 |
| Solanum schippii Standl., 1935 |
| Solanum schizostigma Bitter, 1912 |
| Solanum schlechtendalianum Walp., 1844 |
| Solanum semidemissum Juz., 1937 |
| Solanum setosum (Brandegee) Bitter, 1922 |
| Solanum sideroxyloides Schltdl., 1833 |
| Solanum sideroxyloides subsp. ocellata Bitter, 1919 |
| Solanum sideroxyloides var. ocellatum Donn. Sm., 1889 |
| Solanum siparunoides Ewan, 1952 |
| Solanum solitarium S.F. Blake, 1922 |
| Solanum somniculentum Schltdl., 1847 |
| Solanum sousae S. Knapp, 2010 |
| Solanum spectabile Sendtn., 1954 |