| Piper sancti-felicis Trel., 1927 |
| Piper sanctum (Miq.) Schltdl. ex C. DC., 1869 |
| Piper sarculatum (Trel.) Callejas, 2020 |
| Piper saurodermus Ortiz-Rodr. & J.R. Carral, 2025 |
| Piper scabrum Lam., 1791 |
| Piper schiedeanum Steud., 1841 |
| Piper schippianum Trel. & Standl., 1952 |
| Piper schlechtendalii Steud., 1841 |
| Piper sempervirens (Trel.) Lundell, 1937 |
| Piper sibunense Trel., 1936 |
| Piper silvivagum C. DC., 1899 |
| Piper smilacifolium Kunth, 1816 |
| Piper stevensonii Trel. ex Standl., 1936 |
| Piper stillans Trel. & Standl., 1952 |
| Piper stipulaceum Opiz, 1828 |
| Piper stipulare A.C. Sm., 1943 |
| Piper subampollosum Callejas, 2020 |
| Piper subcitrifolium C. DC., 1920 |
| Piper subeburneum Trel. & Standl., 1952 |
| Piper subsessilifolium C. DC., 1891 |