| Piper curtispicum C. DC., 1897 |
| Piper curvatipes Trel., 1937 |
| Piper cuspidispicum Trel., 1929 |
| Piper darienense C. DC., 1869 |
| Piper davidsonii Yunck., 1950 |
| Piper decipiens (Miq.) C. DC., 1869 |
| Piper decurrens C. DC., 1866 |
| Piper deductum Trel., 1937 |
| Piper dendroamans Trel. ex Callejas, 2020 |
| Piper descourtilsianum C. DC., 1869 |
| Piper diandrum C. DC., 1872 |
| Piper dilatatum Rich., 1792 |
| Piper discolor Trel., 1937 |
| Piper disjunctum C. DC., 1872 |
| Piper distachyon L., 1753 |
| Piper divaricatum G. Mey., 1818 |
| Piper dolichotrichum Yunck., 1952 |
| Piper donnell-smithii C. DC., 1894 |
| Piper dotanum Trel., 1929 |
| Piper dryadum C. DC., 1892 |