| Manfreda petskinil R.A. Orellana, L. Hern. & Carnevali, 2008 |
| Manfreda planifolia (S. Watson) Rose, 1903 |
| Manfreda potosina (B.L. Rob. & Greenm.) Rose, 1903 |
| Manfreda pringlei Rose, 1903 |
| Manfreda pubescens (Regel & Ortgies) Verh.-Will. ex Piña, 1986 |
| Manfreda revoluta (Klotzsch) Rose, 1903 |
| Manfreda rubescens Rose, 1903 |
| Manfreda santana-michelii Art. Castro, Aarón Rodr. & P. Carrillo, 2018 |
| Manfreda scabra (Ortega) McVaugh, 1989 |
| Manfreda sessiliflora (Hemsl.) Matuda, 1960 |
| Manfreda sileri Verh.-Will., 1978 |
| Manfreda singuliflora (S. Watson) Rose, 1903 |
| Manfreda tamazunchalensis Matuda, 1966 |
| Manfreda tigrina (Engelm.) Small ex Rose, 1903 |
| Manfreda umbrophila García-Mend., 2011 |
| Manfreda variegata (Jacobi) Rose, 1903 |
| Manfreda variegata var. sileri Verh.-Will., 1975 |
| Manfreda verhoekiae García-Mend., 2011 |
| Manfreda virginica (L.) Salisb. ex Rose, 1905 |
| Manfreda virginica var. tigrina (Engelm.) Rose, 1903 |